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Genesis 25:24-26 tells us that Esau was born totally covered in red hair, so thick, that it looked like he was wearing clothes. It sounds like he was suffering from hirsutism or hypertrichosis. He would have been perfect for 1970s pornography. Jacob, on the other hand, had the normal amount of hair that you'd expect on a baby, but was quite the heel grabber.
From these two minute details, Isaac gave them their names. The first child would be named Esau, which translates to "hairy", and the second would be named Jacob, which translates to "heel grabber". Isaac really sucks at giving names. The name Jacob is probably better defined as "supplanter". This is due to the difference between its literal translation, and its actual usage. Since, in the end, Jacob supplants his brother as the leader of the family, his name is quite apropos.
As usual, the names assigned to children magically dictate the future of the children. That happens all the time, right? Well, think of everyone you know with the name Eric. Are they presidents? kings? prime ministers? Probably not, but the name Eric means "ruler". Using the bible as a guide for what we should expect, everyone named Eric should be running the world. What gives?